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European Settler’s Affect on Native Americans In 1492 Christopher Columbus made his world famous voyage to the new world, thinking he was traveling to China. Although to the end of his days Columbus believed he had, in fact, landed in China, the evidence he produced pointed to a new unknown world. The new discovery encouraged many Europeans to explore and settle the new world. The Native Americans suffered greatly due to their susceptibility to foreign diseases, and European greed for riches and desire to expand. Between 1518 and 1521 Hernando Cortez lead an expedition of approximately 600 men to the new world in what is now Mexico. There they found the beautiful city of Tenochtitlan where they were, for a while, seen as gods. When war did break loose, Cortez was force