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Impact of European Invasion on Native American Cultures In 1492, Christopher Columbus set upon his voyage to the far east, but ended up reaching a "new and untamed" land. His first and previous voyages, seet into motion a chain of other explorers and voyages. This period, rightly named The Age of Discovery, brought about riches to the European countries who exploited the new world, but also had a huge impact on the Native American cultures of this time. Such factors as diease, loss of territory, and loss of culture, destroyed whole civilizations and nearly ruined others. When Cortes invaded Mexico in 1520, the population