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Of Mice and Men Talk about multi-tasking. Director Gary Sinise takes on the lead role of George in Of Mice and Men. Costarring with him is John Malkovich, playing the slow yet memorable character Lennie, who is uniquely portrayed. The movie does a great job of adapting from the book by John Steinbeck, while adding some great scenes that enhance and bring it together. The movie involves two main characters, George Milton (Sinise), and Lennie Smal