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The play Hamlet, by William Shakespeare, is a classical tragedy takes place in middle age Denmark. The protagonist, Hamlet suffers to carry out revenge for his father, who was killed by Hamletfs uncle, Claudius. At the end of the play, he successes to kill Claudius, but right after that, tragically, he dies as well. During this play, numerous imageries were used in order to create ominous mood to whole play. Among those imageries, that of disease is one of the strongest, and it generates dark, and sinister mood. This imagery is significant to the whole play because not only it foreshadows the ending of this play, it also accounts for expressing negative feelings such as hostility and uneasiness, and allows readers to contrast main characters in the play. The imagery of disease is used throughout the play, and the first one has special significance among them. Marcellus, a night-watch, with Horatio and Hamlet witnesses ghost that looks exactly like former king of Denmark. Hamlet runs after the ghost, to talk, and Marcellus says, gSomething is rotten in the state of Denmarkh, (1, IV, 92) after the event. Not only Marcellusf uneasiness is expressed, but Shakespeare also successes to provide dark, ominous opening.