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Table of Contents I. Abstract II. Introduction III. Key Regulators in G1 Phase -Cyclins -Cyclin Dependent Kinases -Cyclin Dependent Kinase Inhibitors -Rb Pathway -p53 Pathway IV. Current Research -Inhibition of Histone Deacetylation -Restoration of p53 Pathway V. Discussion -Other Applications for Research VI. Conclusion Abstract: This paper reviews current research on G1 phase progression in human cancer. The effects of mutations in cyclins, cyclin dependent kinases, as well as p53 and Rb pathways on cancer onset is also examined. A major regulatory role in G1 phase progression involves extracellular signaling which activates the introduction of the first G1 phase cyclins in the cell. The induction of this early event is important in the completion of later events. If any of the G1 phase cyclins, cyclin dependent kinases, or regulatory pathways responsible for cell cycle control are affected by mutations, abnormal cellular proliferation and cancer is probable. Introduction: The eukaryotic cell cycle is a complex system of checks and balances that ensure the fidelity of cellular proliferation. Over the past few years, there has been considerable interest in the G1 phase of th