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The Truth about Ephedra. It probably goes without saying, but ephedra is one controversial supplement. At times, it’s used in products standardized for ephedrine alkaloids (the active components) with or without the addition of caffeine. I don’t think anyone doubts the published research demonstrating a positive effect of ephedrine and caffeine for weight loss/fat loss or energy enhancement. However, what applies for the synthetic ephedrine may not apply for the herbal “equivalent.” Ephedra is pro