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Neurofibromatosis There are two types of neurofibromatosis: NF1 and NF2. NF1 is benign and NF2 is more severe. This paper is on NF1. Neurofibromatosis is a defective gene on chromosome 17. It is inherited through autosomal dominant genes. It is one of the most commonly inherited genes. About 1/2 of all cases are due to new mutations that are not inherited from parents. The gene is large, and this accounts for the high frequency of new mutations. There are many symptoms associated with neurofibromatosis. Major symptoms include numerous benign tumors, which appear on or under the skin or in deeper areas within the