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The commercialization of many sports have drawn a wider pool of athletes from across the world and thus raised the level of competitiveness and athleticism that is required to play collegiate and professional sports. Physical, psychological, and nutritional components are all avenues that have become vital for the improved performance that is needed to meet these competitive demands. Nutritional supplements have become a billion-dollar industry. Creatine monohydrate is a supplement that has become one of the largest selling supplements in recent years due to its availability and low cost. Many athletes have used creatine for its acclaimed benefits despite the fact these benefits have yet to be clinically proven time and again by laboratory tests. Studies involving athletes from such sports as swimming, rowing, track and field, cycling, and football have shown results both for and against creatine supplementation. The intent of this paper is to analyze the current literature and to outline the possible benefits and side effects of creatine supplementation. Scientists discovered creatine, also known as N-amidinosarcosine, in 1832 (1). Ninety-five percent of the creatine found in the body is in the skeletal muscles (5,6,7)