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Paracetamol In the latter half of the 19th century quinine, made form the bark of the cinchona tree was used as a cure for fever. Because of this the tree became scarcer and cheaper, synthetic alternatives were needed instead. Two of the drugs that were developed for this task included: acetanilide in 1886, and phenacetin in 1887. Both of which had the advantage of possessing both antipyretic and analgesic properties. Paracetamol was in-fact