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Between the mid-fifteenth century and 1700 the most serious diseases were the bubonic plague, sweating disease and scrofula. The cause of bubonic plague was due to the fleas on the black rats. It is believed to have been spread by the crew members of ships transporting spices and silk from the east reaching the main ports in Europe market in 1348. This disease recurred in the above centuries. The cause of the sweating disease was unknown. The soilders at Bosworth Field once they were disbanded and returned to their homes carried the diseases all over England. The scrofula is identified and described by the doctors today as being tuberculosis adentitis, the inflammation of the lymph nodes due to the bacillus of tuberculosis. This disease was not as fatal as the bubonic plague. Throughout Europe, there many shared reactions by people regarding the effects plague and disease had on their society. Each government had to sort out ways to confine the disease so boards of health were established to undertake the day to day supervision of these new regulations. For instance, in October 1568 the stature of pestilence was establihed in Edinburgh. There different levels of isolation through Europe. The English would incarcerate whole hou